IMPORTANCE: Despite clinical benefits and guideline recommendations, uptake of exercise-based cardiac rehabilitation (CR) following coronary artery disease remains suboptimal, with barriers including transportation issues, travel distance, and geographic location. To overcome…
Calcific aortic valve disease (CAVD) leads to aortic stenosis (AS) through inflammation and fibro-calcific remodeling. Although CAVD and atherosclerosis share features, not all patients with AS develop atherosclerotic cardiovascular disease (ASCVD), suggesting mechanistic…
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Acute pericarditis, or inflammation of the pericardial sac, is a common cause of chest pain with a broad range of etiologies, including viral, bacterial, traumatic, rheumatologic, and malignant causes; however, most cases are idiopathic. Acute pericarditis is associated with the…
BACKGROUND: Comparative evidence for M-TEER performed at centers with versus without on-site cardiac surgery is lacking. We compared early outcomes at two centers that shared the same interventional operator team but differed in the availability of on-site cardiac surgery.…
BACKGROUND: Anomalous Aortic Origin of a Coronary Artery (AAOCA) high-risk anatomical features (intramural segment, acute take-off angle, slit-like ostium) cause coronary stenosis leading to myocardial infarction. How these features alter coronary physiology remains unclear.…
Pericardiectomy for constrictive pericarditis remains a high-risk operation, and early outcomes are inadequately predicted by conventional cardiac risk models despite the high prevalence of chronic hepatic congestion in this population. We performed a retrospective observational…
Cardiac angiosarcoma is a rare and aggressive malignancy with limited therapeutic options, and its molecular features remain poorly defined. This study sought to characterize the genomic and transcriptomic landscape of cardiac angiosarcoma and to explore molecular features…
BackgroundDi(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in polyvinyl chloride medical devices employed during cardiopulmonary bypass (CPB). Although migration from these devices and blood-storage systems has long been recognized, the human clinical evidence…
OBJECTIVES: Body mass index (BMI) is associated with adverse perioperative outcomes. This study investigated the completeness of ethnicity and socioeconomic status (SES) reporting in perioperative research and the association between BMI and perioperative outcomes by ethnicity…
BACKGROUND: Lower socioeconomic status conveys a known survival disadvantage for patients with esophageal adenocarcinoma (EAC). The potential role of the treating center volume in mitigating this disparity has not been described to date. METHODS: Non-metastatic EAC patients were…
BACKGROUND: Postoperative sepsis and/or systemic inflammatory response syndrome caused by infective endocarditis (IE) can lead to significant postoperative mortality. Intraoperative hemoadsorption therapy has shown promising results in the treatment of sepsis and dysregulated…
Postoperative blood pressure fluctuations after cardiac surgery are highly clinically relevant, yet analyzing high-frequency arterial pressure data remains challenging. In this study, we introduce a novel methodology for processing minute-by-minute postoperative intensive care…
BACKGROUND: Effective postoperative analgesia is critical to recovery after cardiac surgery. Continuous wound infiltration (CWI) with local anesthetics (LAs) has been proposed as an opioid-sparing adjunct, but its efficacy beyond pain control and its safety profile remain…
BACKGROUND: Cardiogenic shock (CS) is a critical syndrome with a very high fatality rate, and in-hospital mortality ranges from 27% to 51%. Among the various prognostic approaches, serum biomarkers have attracted considerable attention because they are easy to measure,…
Organ dysfunction can develop after cardiac surgery even when mean arterial pressure, cardiac output, hemoglobin, temperature, and pump flow meet conventional targets. These variables remain the safety foundation, but they do not directly establish exchange-capable capillary…
BACKGROUND: Intraoperative hypotension (IOH) is a common and potentially preventable complication strongly associated with postoperative acute kidney injury, myocardial injury, and mortality. Current approaches to IOH management remain largely reactive, and existing prediction…
Long term xenografts often fail in association with evidence of coagulation pathway dysregulation, which may be caused in part by the inefficient binding of inactivated protein C (PC) to porcine thrombomodulin (TBM). This study evaluates the effect of human TBM (hTBM) expression…